Growth Factors & Cytokines

Recombinant Human CTGFL/WISP-2

0 ReviewsSubmit a Review

Product Details

Catalogue Number: 120-16
Description:

CTGFL/WISP-2 is a 28.6 kDa protein that belongs to the CCN family of cysteine-rich regulatory proteins. Members of this family stimulate mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest, and migration of multiple cell types. The protein is expressed in primary osteoblasts, fibroblasts, the ovaries, testes, and heart. In addition to promoting adhesion of osteoblasts, CTGFL/WISP-2 inhibits osteocalcin production, as well as binding of fibrinogen to integrin receptors. Recombinant Human CTGFL/WISP-2 is a 24.3 kDa protein consisting of 228 amino acid residues. Mature human CTGFL/WISP-2 is a 24.8 kDa polypeptide protein containing 227 amino acids. It is composed of 3 distinct domains; the IGF-Binding Protein domain (IGF-BP), the Thrombospondin type I repeat (TSP type I), and von Willebrand Factor C motif (VWFC).

Source: E.coli

Synonyms: Connective Tissue Growth Factor-Like protein, CCN5, CT-58

AA Sequence: MQLCPTPCTC PWPPPRCPLG VPLVLDGCGC CRVCARRLGE PCDQLHVCDA SQGLVCQPGA GPGGRGALCL LAEDDSSCEV NGRLYREGET FQPHCSIRCR CEDGGFTCVP LCSEDVRLPS WDCPHPRRVE VLGKCCPEWV CGQGGGLGTQ PLPAQGPQFS GLVSSLPPGV PCPEWSTAWG PCSTTCGLGM ATRVSNQNRF CRLETQRRLC LSRPCPPSRG RSPQNSAF

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 was determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is between 10-20 ng/ml in the presence of 15 ng/ml of human IGF-II.

Calculated Molecular Weight: 24.3 kDa

Accession Number: O76076

Gene ID: 8839

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Hong, S P
Title
Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi
Citation
Nature Communications; 11(1) pg4102
PubMed Id
First Author
Brown, B A
Title
Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells.
Citation
Aging Cell; 18(1) pge12844
PubMed Id