Recombinant Human Fractalkine (CX3CL1) 0 ComentariosSubmit a Review Detalles del Producto Nùmero de Catalogo 300-31 Descripcion Fractalkine is a CX3CL chemokine that signals through the CX3CR1 receptor. Fractalkine has been shown to chemoattract monocytes, microglia cells and NK cells. Fractalkine is, at this time, the only CXC3C chemokine that contains three amino acid residues between the first and second cysteine residues of the chemokine domain. The Fractalkine gene encodes for a 397 amino acid precursor protein containing a 24 amino acid signal sequence, a chemokine domain, and a "mucin-like stalk" sequence, which is followed by the transmembrane domain containing approximately 20 amino acids, and a C-terminal cytoplasmic domain. The extracellular chemokine domain contains 76 amino acid residues, including the four conserved cysteine residues found in other chemokines. Recombinant Human Fractalkine is an 8.5 kDa protein containing 76 amino acid residues, including the four conserved cysteine residues present in CC chemokines. Source: E.coli Synonyms: Neurotactin, CX3CL1, FKN AA Sequence: QHHGVTKCNI TCSKMTSKIP VALLIHYQQN QASCGKRAII LETRQHRLFC ADPKEQWVKD AMQHLDRQAA ALTRNG Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human T cells using a concentration range of 5.0-10.0 ng/ml. Calculated Molecular Weight: 8.5 kDa Accession Number: P78423 Gene ID: 6376 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Human, Human + Virus, Monkey, Mouse, Rat References PubMed SDS Búsqueda del CoA Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Angiogenesis/Cardiovascular Apoptosis Cancer Chemotaxis Immune System Inflammation Neurobiology Wound Healing product.subtitle.recentcitations Primer autor Park, J Titulo Multi-Omics-Based Autophagy-Related Untypical Subtypes in Patients with Cerebral Amyloid Pathology. Citar Advanced science (Weinheim, Baden-Wurttemberg, Germany); 9(23) pge2201212 PudMed id 35694866 Primer autor Magusali, N Titulo A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene. Citar Brain : A Journal Of Neurology; 144(12) pg3727-3741 PudMed id 34619763 Primer autor De Groof, T W Titulo Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies Citar Nature Communications; 12(1) pg4357 PudMed id 34272386