Recombinant Human Galectin-3 0 ComentariosSubmit a Review Detalles del Producto Nùmero de Catalogo 450-38 Descripcion Lectins, of either plant or animal origin, are carbohydrate-binding proteins that interact with glycoproteins and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with β-galactoside moieties. Galectin-3 regulates a number of biological processes, including embryogenesis, inflammatory responses, cell progression and metastasis. Galectin-3 is normally expressed in epithelia of a variety of tissues, including colon and endometrium, and in various inflammatory cells, including macrophages. Galectin-3 can function intracellularly, controlling the cell cycle and preventing T-cell apoptosis, and also extracellularly, by activating various cells, including monocytes/macrophages, mast cells, neutrophils, and lymphocytes. Expression of Galectin-3 is affected by neoplastic transformation, being up-regulated in certain types of lymphomas, and in thyroid and hepatic carcinomas. Conversely, it is down-regulated in other cancers such as colon, breast, ovarian, and uterine. Recombinant Human Galectin-3 is a globular 26.0 kDa protein containing 249 amino acid residues, but no disulfide bonds. Source: E.coli Synonyms: Galactose-specific lectin-3, IgE-binding protein, MAC2, L-29, CPB-35 AA Sequence: ADNFSLHDAL SGSGNPNPQG WPGAWGNQPA GAGGYPGASY PGAYPGQAPP GAYPGQAPPG AYHGAPGAYP GAPAPGVYPG PPSGPGAYPS SGQPSAPGAY PATGPYGAPA GPLIVPYNLP LPGGVVPRML ITILGTVKPN ANRIALDFQR GNDVAFHFNP RFNENNRRVI VCNTKLDNNW GREERQSVFP FESGKPFKIQ VLVEPDHFKV AVNDAHLLQY NHRVKKLNEI SKLGISGDID LTSASYTMI Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human blood monocytes. Chemotactic activity was observed at a concentration of 2.5 µg/ml with a peak response obtained at 250 µg/ml. Calculated Molecular Weight: 26 kDa Accession Number: P17931 Gene ID: 3958 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, References PubMed SDS Búsqueda del CoA Product Line Country Of Origin: USA Not for human use. Research Interest Apoptosis Cancer Immune System Inflammation Neurobiology product.subtitle.recentcitations Primer autor Nagasaki, A Titulo Odontogenic infection by Porphyromonas gingivalis exacerbates fibrosis in NASH via hepatic stellate cell activation. Citar Scientific Reports; 10(1) pg4134 PudMed id 32139740 Primer autor Chen, X Titulo Galectin-3 exacerbates ox-LDL-mediated endothelial injury by inducing inflammation via integrin β1-RhoA-JNK signaling activation. Citar Journal of Cellular Physiology; 234(7) pg10990-11000 PudMed id 30536538 Primer autor Sweeney, J G Titulo Loss of GCNT2/I-branched glycans enhances melanoma growth and survival. Citar Nature Communications; 9(1) pg3368 PudMed id 30135430