Chemokines

Recombinant Human GCP-2 (CXCL6)

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Product Details

Catalogue Number: 300-41
Description:

CXCL6, also known as GCP-2 in humans, is a connective tissue-derived CXC chemokine that can signal through the CXCR1 and CXCR2 receptors.  Human GCP-2, which is cross-reactive with murine cells, selectively attracts neutrophils, and has also been shown to exert anti-angiogenic activity. Recombinant Human GCP-2 is a 7.9 kDa protein containing 72 amino acid residues.

Source: E.coli

Synonyms: Granulocyte Chemotactic Protein-2, CXCL6, LIX (murine)

AA Sequence: VLTELRCTCL RVTLRVNPKT IGKLQVFPAG PQCSKVEVVA SLKNGKQVCL DPEAPFLKKV IQKILDSGNK KN

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human neutrophils using a concentration range of 10.0-50.0 ng/ml.

Calculated Molecular Weight: 7.9 kDa

Accession Number: P80162

Gene ID: 6372

Note:

1mg will be provided as 2x500μg.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Rosenkilde, M M
Title
The CXC chemokine receptor encoded by herpesvirus saimiri, ECRF3, shows ligand-regulated signaling through Gi, Gq, and G12/13 proteins but constitutive signaling only through Gi and G12/13 proteins.
Citation
The Journal of Biological Chemistry; 279(31) pg32524-33
PubMed Id
First Author
Singh, K
Title
Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.
Citation
Scientific Reports; 7(1) pg4267
PubMed Id
First Author
Waldhoer, M
Title
The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis.
Citation
The Journal of Biological Chemistry; 278(21) pg19473-82
PubMed Id