Recombinant Human IFN-λ2 0 ReviewsSubmit a Review Product Details Catalogue Number: 300-02K Description: IFNλ1, 2, and 3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and interferons. All three IFN-lambdas use a distinct receptor system composed of an IFN-λR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14). Signaling through this receptor system induces antiviral defenses similar to, but distinct from, than that of type I interferons. Recombinant Human IFN-λ2 is a 19.6 kDa protein containing 174 amino acid residues. Source: E.coli Synonyms: IL-28A AA Sequence: PVARLHGALP DARGCHIAQF KSLSPQELQA FKRAKDALEE SLLLKDCRCH SRLFPRTWDL RQLQVRERPM ALEAELALTL KVLEATADTD PALVDVLDQP LHTLHHILSQ FRACIQPQPT AGPRTRGRLH HWLYRLQEAP KKESPGCLEA SVTFNLFRLL TRDLNCVASG DLCV Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.3-0.5 ng/ml. Calculated Molecular Weight: 19.6 kDa Accession Number: Q8IZJ0 Gene ID: 282616 crossreactivity: Human, References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Diabetes/Weight Regulation Immune System product.subtitle.recentcitations First Author Stanifer, M L Title Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells. Citation Cell Reports; 32(1) pg107863 PubMed Id 32610043 First Author Duong, F H Title IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-λ3 genotype and with nonresponsiveness to IFN-α therapies. Citation The Journal of Experimental Medicine; 211(5) pg857-68 PubMed Id 24752298 First Author Krenn, V Title Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly. Citation Cell Stem Cell; 28(8) pg1362-1379.e7 PubMed Id 33838105
