Recombinant Human IL-15

Product Details

Catalogue Number: 200-15

Description:

IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activities primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been linked to rheumatoid arthritis, inflammatory bowel disease, and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant Human IL-15 is a 12.9 kDa protein consisting of 115 amino acid residues.

Source: E.coli

Synonyms: Interleukin-15, IL-T

AA Sequence: MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of CTLL-2 cells was found to be ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 10⁶ units/mg.

This product has been tested against the WHO standard. International Unit information can be found here.

Calculated Molecular Weight: 12.9 kDa

Accession Number: P40933

Gene ID: 3600

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

crossreactivity:

Bacteria, Cow, Human, Human + Hamster, Human + Mouse, Monkey, Mouse, Mouse + Virus, Rat

Country Of Origin: USA

Not for human use.

Research Interest

Stem Cells & Differentiation

product.subtitle.recentcitations

First Author

Wang, W

Title

Hepatobiliary Tumor Organoids Reveal HLA Class I Neoantigen Landscape and Antitumoral Activity of Neoantigen Peptide Enhanced with Immune Checkpoint Inhibitors.

Citation

Advanced science (Weinheim, Baden-Wurttemberg, Germany); 9(22) pge2105810

PubMed Id

35665491

First Author

Moosmann, C

Title

Orthotopic T-cell receptor replacement in primary human T cells using CRISPR-Cas9-mediated homology-directed repair.

Citation

STAR Protocols; 3(1) pg101031

PubMed Id

34977677

First Author

Matis, S

Title

LINC00152 expression in normal and Chronic Lymphocytic Leukemia B cells.

Citation

Hematological Oncology; 40(1) pg40-47

PubMed Id

34679195

product.subtitle.productreviews

Existing reviews

CD8 stimulation culture

When used at 10 ng/mL, it promoted the survival and expansion of human CD8+ T cells. Cells were stimulated with anti-CD3/anti-CD28 for 2 days in the presence of rhIL-15 and then expanded for 6 days in the presence of rhIL-15 alone.

From: Michael | Date: 08/08/2023

Growth Factors & Cytokines