Recombinant Human IL-15 0 ReviewsSubmit a Review Product Details Catalogue Number: 200-15 Description: IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activities primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been linked to rheumatoid arthritis, inflammatory bowel disease, and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant Human IL-15 is a 12.9 kDa protein consisting of 115 amino acid residues. Source: E.coli Synonyms: Interleukin-15, IL-T AA Sequence: MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 cells was found to be ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 12.9 kDa Accession Number: P40933 Gene ID: 3600 crossreactivity: Bacteria, Cow, Human, Human + Hamster, Human + Mouse, Monkey, Mouse, Mouse + Virus, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest CAR T Cell AIDS/HIV Apoptosis Cancer Cell Culture Immune System Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations First Author Hebbar, N Title CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cells. Citation Nature Communications; 13(1) pg587 PubMed Id 35102167 First Author Banskota, S Title Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins. Citation Cell; 185(2) pg250-265.e16 PubMed Id 35021064 First Author Moosmann, C Title Orthotopic T-cell receptor replacement in primary human T cells using CRISPR-Cas9-mediated homology-directed repair. Citation STAR Protocols; 3(1) pg101031 PubMed Id 34977677
