Recombinant Human IL-15 1 ReviewsSubmit a Review Product Details Catalogue Number: 200-15 Description: IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activities primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been linked to rheumatoid arthritis, inflammatory bowel disease, and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant Human IL-15 is a 12.9 kDa protein consisting of 115 amino acid residues. Source: E.coli Synonyms: Interleukin-15, IL-T AA Sequence: MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 cells was found to be ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 12.9 kDa Accession Number: P40933 Gene ID: 3600 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Cow, Human, Human + Hamster, Human + Mouse, Monkey, Mouse, Mouse + Virus, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest CAR T Cell AIDS/HIV Apoptosis Cancer Cell Culture Immune System Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations First Author Wang, W Title Hepatobiliary Tumor Organoids Reveal HLA Class I Neoantigen Landscape and Antitumoral Activity of Neoantigen Peptide Enhanced with Immune Checkpoint Inhibitors. Citation Advanced science (Weinheim, Baden-Wurttemberg, Germany); 9(22) pge2105810 PubMed Id 35665491 First Author Moosmann, C Title Orthotopic T-cell receptor replacement in primary human T cells using CRISPR-Cas9-mediated homology-directed repair. Citation STAR Protocols; 3(1) pg101031 PubMed Id 34977677 First Author Matis, S Title LINC00152 expression in normal and Chronic Lymphocytic Leukemia B cells. Citation Hematological Oncology; 40(1) pg40-47 PubMed Id 34679195 product.subtitle.productreviews Existing reviews CD8 stimulation culture When used at 10 ng/mL, it promoted the survival and expansion of human CD8+ T cells. Cells were stimulated with anti-CD3/anti-CD28 for 2 days in the presence of rhIL-15 and then expanded for 6 days in the presence of rhIL-15 alone. From: Michael | Date: 08/08/2023 × CD8 stimulation culture When used at 10 ng/mL, it promoted the survival and expansion of human CD8+ T cells. Cells were stimulated with anti-CD3/anti-CD28 for 2 days in the presence of rhIL-15 and then expanded for 6 days in the presence of rhIL-15 alone. From: Michael | Date: 08/08/2023 Close
