Recombinant Human IL-17A 0 ReviewsSubmit a Review Product Details Catalogue Number: 200-17 Description: The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains that are secreted by activated T-cells, which act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant Human IL-17A is a 31.3 kDa, disulfide-linked homodimer of two 137 amino acid, polypeptide chains. Source: E.coli Synonyms: IL-17, CTLA-8 AA Sequence (monomer): MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Measured by its ability to induce GROα production by HT-29 cells, using a concentration range of 0.5-5.0 ng/ml. Calculated Molecular Weight: 31.3 kDa Accession Number: Q16552 Gene ID: 3605 crossreactivity: Cow, Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 AIDS/HIV Angiogenesis/Cardiovascular Immune System Inflammation product.subtitle.recentcitations First Author Edwards, L A Title Delineation of the innate and adaptive T-cell immune outcome in the human host in response to Campylobacter jejuni infection. Citation PLoS ONE; 5(11) pge15398 PubMed Id 21085698 First Author Ersvaer, E Title Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells. Citation BMC Immunology; 11 pg38 PubMed Id 20618967 First Author Cochaud, S Title IL-17A is produced by breast cancer TILs and promotes chemoresistance and proliferation through ERK1/2. Citation Scientific Reports; 3 pg3456 PubMed Id 24316750
