Growth Factors & Cytokines

Recombinant Human IL-17A

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Product Details

Catalogue Number: 200-17
Description:

The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains that are secreted by activated T-cells, which act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules.  Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles.  The six known members of this family, IL-17A through IL-17F, are secreted as homodimers.  IL-17A exhibits cross-species bioactivity between human and murine cells.  Recombinant Human IL-17A is a 31.3 kDa, disulfide-linked homodimer of two 137 amino acid, polypeptide chains.

Source: E.coli

Synonyms: IL-17, CTLA-8

AA Sequence (monomer): MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Measured by its ability to induce GROα production by HT-29 cells, using a concentration range of 0.5-5.0 ng/ml.

Calculated Molecular Weight: 31.3 kDa

Accession Number: Q16552

Gene ID: 3605

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Edwards, L A
Title
Delineation of the innate and adaptive T-cell immune outcome in the human host in response to Campylobacter jejuni infection.
Citation
PLoS ONE; 5(11) pge15398
PubMed Id
First Author
Ersvaer, E
Title
Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells.
Citation
BMC Immunology; 11 pg38
PubMed Id
First Author
Cochaud, S
Title
IL-17A is produced by breast cancer TILs and promotes chemoresistance and proliferation through ERK1/2.
Citation
Scientific Reports; 3 pg3456
PubMed Id