Recombinant Human IL-17E 0 ReviewsSubmit a Review Product Details Catalogue Number: 200-24 Description: IL-17E is a disulfide-linked homodimer of two 145 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17E stimulates secretion of IL-8, and induces activation of the transcription factor NF-κB in cells that express the IL-17BR receptor. Recombinant Human IL-17E is a 33.8 kDa disulfide-linked homodimer of two 146 amino acid polypeptide chains. Source: E.coli Synonyms: Interleukin-17E, IL-25 AA Sequence (monomer): MYSHWPSCCP SKGQDTSEEL LRWSTVPVPP LEPARPNRHP ESCRASEDGP LNSRAISPWR YELDRDLNRL PQDLYHARCL CPHCVSLQTG SHMDPRGNSE LLYHNQTVFY RRPCHGEKGT HKGYCLERRL YRVSLACVCV RPRVMG Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10-100 ng/ml. Calculated Molecular Weight: 33.8 kDa Accession Number: Q9H293 Gene ID: 64806 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 1mg will be provided as 2x500μg. crossreactivity: Human, References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Cancer Immune System Inflammation product.subtitle.recentcitations First Author Han, K Title A Pilot Study To Investigate the Immune-Modulatory Effects of Fasting in Steroid-Naive Mild Asthmatics. Citation Journal of immunology (Baltimore, Md. : 1950); 201(5) pg1382-1388 PubMed Id 30021766 First Author Silacci, M Title Linker length matters, fynomer-Fc fusion with an optimized linker displaying picomolar IL-17A inhibition potency. Citation The Journal of Biological Chemistry; 289(20) pg14392-8 PubMed Id 24692552
