Growth Factors & Cytokines

Recombinant Human IL-1RA

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Product Details

Catalogue Number: 200-01RA
Description:

Interleukin-1 receptor antagonist (IL-1RA) is a naturally-occurring, inflammatory-inhibitor protein.  It inhibits the activity of IL-1α and IL-1β by competitively blocking their binding to type I and type II receptors.  IL-1RA is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts.  Therapeutically, IL-1RA may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease.  Recombinant Human IL-1RA is a 17.2 kDa protein consisting of 153 amino acid residues.

Source: E.coli

AA Sequence: MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE

Synonyms: IL-1Ra, ICIL-1RA, IRAP, IL-1RN

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit the IL-1α stimulation of murine D10S cell. The expected ED50 is 20-40 ng/ml in the presence of 50 pg/ml of IL-1α.

Calculated Molecular Weight: 17.2 kDa

Accession Number: P14778

Gene ID: 3554

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Ersvaer, E
Title
Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells.
Citation
BMC Immunology; 11 pg38
PubMed Id
First Author
Prieto, G A
Title
Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 112(36) pgE5078-87
PubMed Id
First Author
Bouhaddou, M
Title
The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
Citation
Cell; 182(3) pg685-712.e19
PubMed Id