Recombinant Human IL-24 0 ComentariosSubmit a Review Detalles del Producto Nùmero de Catalogo 200-35 Descripcion IL-24 is a secreted glycoprotein belonging to the IL-10 structural family of cytokines. It is produced by a variety of cell types, including B cells, CD4+ cells, NK cells, lymph node DCs, monocytes, and melanoma cells. IL-24 can signal through the IL20R1/IL20R2 and IL22R1/IL20R2 receptors to initiate a signaling cascade, which includes the induction of JAK1/STAT3 phosphorylation. IL-24 is, functionally, a pleiotropic protein, but is generally characterized as an anti-cancer cytokine that can selectively inhibit growth of a wide variety of human cancer cells through activities that include: the induction of differentiation and apoptosis; and the suppression of angiogenesis and cell proliferation. Recombinant Human IL-24 is an 18.9 kDa glycoprotein that contains 161 amino acid residues, including a C-terminal His-tag. Source: CHO cells Synonyms: Interleukin-24, MDA-7 (Melanoma differentiation-association gene 7 protein) AA Sequence: QEFHFGPCQV KGVVPQKLWE AFWAVKDTMQ AQDNITSARL LQQEVLQNVS DAESCYLVHT LLEFYLKTVF KNYHNRTVEV RTLKSFSTLA NNFVLIVSQL QPSQENEMFS IRDSAHRRFL LFRRAFKQLD VEAALTKALG EVDILLTWMQ KFYKLHHHHH H Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Not available. Calculated Molecular Weight: 18.9 kDa Accession Number: Q13007 Gene ID: 11009 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 1mg will be provided as 2x500μg. crossreactivity: Human References PubMed SDS Búsqueda del CoA Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Cancer Immune System product.subtitle.recentcitations Primer autor Jiménez-Andrade, Y Titulo The Developmental Transcription Factor p63 Is Redeployed to Drive Allergic Skin Inflammation through Phosphorylation by p38α. Citar Journal of immunology (Baltimore, Md. : 1950); 208(12) pg2613-2621 PudMed id 35623662 Primer autor Cutano, V Titulo HDAC7-mediated control of tumour microenvironment maintains proliferative and stemness competence of human mammary epithelial cells. Citar Molecular Oncology; 13(8) pg1651-1668 PudMed id 31081251 Primer autor Wei, Z Titulo Vitamin D Switches BAF Complexes to Protect β Cells. Citar Cell; 173(5) pg1135-1149.e15 PudMed id 29754817