Growth Factors & Cytokines

Recombinant Human IL-3

Product Details

Catalogue Number: 200-03
Description:
Recombinant Human IL-3

IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages.  Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoiesis, phagocytosis, and antibody-mediated cellular cytotoxicity.  Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles.  Many of the IL-3 activities depend upon co-stimulation with other cytokines.  IL-3 is a species-specific, variably glycosylated cytokine.  Recombinant Human IL-3 is a 15.0 kDa globular protein containing 133 amino acid residues.

Source: E.coli

Synonyms: Interleukin-3, MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor

AA Sequence: APMTQTTSLK TSWVNCSNMI DEIITHLKQP PLPLLDFNNL NGEDQDILME NNLRRPNLEA FNRAVKSLQN ASAIESILKN LLPCLPLATA APTRHPIHIK DGDWNEFRRK LTFYLKTLEN AQAQQTTLSL AIF

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.

This product has been tested against the WHO standard. International Unit information can be found here.

Calculated Molecular Weight: 15 kDa

Accession Number: P08700

Gene ID: 3562

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Ackermann, M
Title
Continuous human iPSC-macrophage mass production by suspension culture in stirred tank bioreactors.
Citation
Nature Protocols; 17(2) pg513-539
PubMed Id
First Author
Wang, Y
Title
Using Cryo-ET to distinguish platelets during pre-acute myeloid leukemia from steady state hematopoiesis.
Citation
Communications Biology; 5(1) pg72
PubMed Id
First Author
Díaz de la Guardia, R
Title
Engraftment characterization of risk-stratified AML in NSGS mice.
Citation
Blood Advances; 5(23) pg4842-4854
PubMed Id

product.subtitle.productreviews

Existing reviews
IL3 for iPSC differentiation
Much cheaper than other options present in the market and extremely efficient. I'd highly recommend it as it is easy to reconstitute and very dependable.
From:  Meenakshi | Date:  09/07/2020