Recombinant Human IL-36γ (IL-1F9) 0 ReviewsSubmit a Review Product Details Catalogue Number: 200-36G Description: The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36 α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36γ is highly expressed in psoriatic plaques and in tissues containing epithelial cells. IL-36γ signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36γ also functions as an agonist of NF-κB, and can stimulate the inflammatory response in bronchial epithelial cells. Recombinant Human IL-36γ is a 17.0 kDa protein containing 152 amino acid residues. Source: E.coli Synonyms: Interleukin-36γ, IL-1F, IL-1ε (epsilon), IL-1H1 AA Sequence: SMCKPITGTI NDLNQQVWTL QGQNLVAVPR SDSVTPVTVA VITCKYPEAL EQGRGDPIYL GIQNPEMCLY CEKVGEQPTL QLKEQKIMDL YGQPEPVKPF LFYRAKTGRT STLESVAFPD WFIASSKRDQ PIILTSELGK SYNTAFELNI ND Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Measured by its ability to induce IL-8 production by human PBMCs. Calculated Molecular Weight: 17 kDa Accession Number: Q9NZH8 Gene ID: 56300 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Cancer Diabetes/Weight Regulation Immune System Inflammation Neurobiology Wound Healing product.subtitle.recentcitations First Author Gao, Y Title IL-36γ Promotes Killing of Mycobacterium tuberculosis by Macrophages via WNT5A-Induced Noncanonical WNT Signaling. Citation Journal of Immunology; 203(4) pg922-935 PubMed Id 31235551 First Author Ahsan, F Title IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis. Citation Scientific Reports; 8(1) pg1520 PubMed Id 29367626
