Recombinant Human IL-5 0 ReviewsSubmit a Review Product Details Catalogue Number: 200-05 Description: IL-5 is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils. Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Human and murine IL-5 is cross-species reactive. Recombinant Human IL-5 is a 26.5 kDa disulfide-linked homodimeric protein containing two 116 amino acid chains. Source: E.coli Synonyms: EDF, BCDFII, TRF AA Sequence: MIPTEIPTSA LVKETLALLS THRTLLIANE TLRIPVPVHK NHQLCTEEIF QGIGTLESQT VQGGTVERLF KNLSLIKKYI DGQKKKCGEE RRRVNQFLDY LQEFLGVMNT EWIIES Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent proliferation of TF-1 cells was ≤ 0.15 ng/ml, corresponding to a specific activity of ≥ 6.6 x 106 units/mg. Calculated Molecular Weight: 26.5 kDa Accession Number: P05113 Gene ID: 3567 crossreactivity: Guinea Pig, Human, Monkey, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Immune System Inflammation Stem Cells & Differentiation Wound Healing Allergy product.subtitle.recentcitations First Author Jenkins, M R Title Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time. Citation The Journal of Experimental Medicine; 212(3) pg307-17 PubMed Id 25732304 First Author de Bruin, A M Title Eosinophil differentiation in the bone marrow is inhibited by T cell-derived IFN-gamma. Citation Blood; 116(14) pg2559-69 PubMed Id 20587787 First Author Pieters, T Title Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice. Citation The Journal of Experimental Medicine; 218(10) PubMed Id 34406363
