Growth Factors & Cytokines

Recombinant Human IL-6

Product Details

Catalogue Number: 200-06
Description:
Recombinant Human IL-6

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant Human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.

Source: E.coli

Synonyms: Interleukin-6, 26 kDa protein, IFN-β2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2

AA Sequence: PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate the proliferation of mouse B9 cells. The expected ED50 range is 0.001 - 0.020 ng/ml.

Calculated Molecular Weight: 20.9 kDa

Accession Number: P05231

Gene ID: 3569

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Knecht, S
Title
Interval-Based Secretomics Unravels Acute-Phase Response in Hepatocyte Model Systems.
Citation
Molecular & cellular proteomics : MCP; 21(6) pg100241
PubMed Id
First Author
Badloe, F M
Title
A Novel Method for Total IgE Purification from Human Serum.
Citation
Journal of immunology (Baltimore, Md. : 1950); 208(10) pg2436-2442
PubMed Id
First Author
Wang, Q
Title
Histone H1.2 promotes hepatocarcinogenesis by regulating signal transducer and activator of transcription 3 signaling.
Citation
Cancer Science; 113(5) pg1679-1692
PubMed Id

product.subtitle.productreviews

Existing reviews
Quality product, Quick Arrival
The IL-6 protein that we bought works seamlessly in our research and the best part is the day or two turnaround time to receive it after placing an order.
From:  Todd | Date:  27/08/2020