Recombinant Human IL-6 1 ReviewsSubmit a Review Product Details Catalogue Number: 200-06 Description: IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant Human IL-6 is a 20.9 kDa protein containing 184 amino acid residues. Source: E.coli Synonyms: Interleukin-6, 26 kDa protein, IFN-β2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2 AA Sequence: PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of mouse B9 cells. The expected ED50 range is 0.001 - 0.020 ng/ml. Calculated Molecular Weight: 20.9 kDa Accession Number: P05231 Gene ID: 3569 crossreactivity: Bacteria, Cow, Human, Human + Hamster, Human + Mouse, Human + Virus, Monkey, Mouse, Pig, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Cancer Cell Culture Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Allergy Transplantation product.subtitle.recentcitations First Author Knecht, S Title Interval-Based Secretomics Unravels Acute-Phase Response in Hepatocyte Model Systems. Citation Molecular & cellular proteomics : MCP; 21(6) pg100241 PubMed Id 35525403 First Author Badloe, F M Title A Novel Method for Total IgE Purification from Human Serum. Citation Journal of immunology (Baltimore, Md. : 1950); 208(10) pg2436-2442 PubMed Id 35523453 First Author Wang, Q Title Histone H1.2 promotes hepatocarcinogenesis by regulating signal transducer and activator of transcription 3 signaling. Citation Cancer Science; 113(5) pg1679-1692 PubMed Id 35294987 product.subtitle.productreviews Existing reviews Quality product, Quick Arrival The IL-6 protein that we bought works seamlessly in our research and the best part is the day or two turnaround time to receive it after placing an order. From: Todd | Date: 27/08/2020 × Quality product, Quick Arrival The IL-6 protein that we bought works seamlessly in our research and the best part is the day or two turnaround time to receive it after placing an order. From: Todd | Date: 27/08/2020 Close
