Recombinant Human Leptin 0 ReviewsSubmit a Review Product Details Catalogue Number: 300-27 Description: Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Human Leptin is a 16.0 kDa protein containing 147 amino acid residues. Source: E.coli Synonyms: Obesity protein (OB) AA Sequence: MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSSKQKVTGL DFIPGLHPIL TLSKMDQTLA VYQQILTSMP SRNVIQISND LENLRDLLHV LAFSKSCHLP WASGLETLDS LGGVLEASGY STEVVALSRL QGSLQDMLWQ LDLSPGC Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: PeproTech's Human Leptin is biologically active in the ob/ob mouse obesity model. The ob/ob mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed compared to saline-treated controls. Calculated Molecular Weight: 16 kDa Accession Number: P41159 Gene ID: 3952 crossreactivity: Bacteria, Chicken, Human, Monkey, Mouse, Pig, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Diabetes/Weight Regulation Immune System Inflammation Neurobiology Wound Healing product.subtitle.recentcitations First Author Lundåsen, T Title Leptin induces the hepatic high density lipoprotein receptor scavenger receptor B type I (SR-BI) but not cholesterol 7alpha-hydroxylase (Cyp7a1) in leptin-deficient (ob/ob) mice. Citation The Journal of Biological Chemistry; 278(44) pg43224-8 PubMed Id 12917427 First Author Iqbal, J Title Leptin-mediated differential regulation of microsomal triglyceride transfer protein in the intestine and liver affects plasma lipids. Citation The Journal of Biological Chemistry; 295(13) pg4101-4113 PubMed Id 32047110 First Author Maedler, K Title Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets. Citation Proceedings of the National Academy of Sciences of the United States of America; 101(21) pg8138-43 PubMed Id 15141093
