Growth Factors & Cytokines

Recombinant Human Leptin

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Product Details

Catalogue Number: 300-27
Description:

Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Human Leptin is a 16.0 kDa protein containing 147 amino acid residues.

Source: E.coli

Synonyms: Obesity protein (OB)

AA Sequence: MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSSKQKVTGL DFIPGLHPIL TLSKMDQTLA VYQQILTSMP SRNVIQISND LENLRDLLHV LAFSKSCHLP WASGLETLDS LGGVLEASGY STEVVALSRL QGSLQDMLWQ LDLSPGC

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: PeproTech's Human Leptin is biologically active in the ob/ob mouse obesity model. The ob/ob mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed compared to saline-treated controls.

Calculated Molecular Weight: 16 kDa

Accession Number: P41159

Gene ID: 3952

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Lundåsen, T
Title
Leptin induces the hepatic high density lipoprotein receptor scavenger receptor B type I (SR-BI) but not cholesterol 7alpha-hydroxylase (Cyp7a1) in leptin-deficient (ob/ob) mice.
Citation
The Journal of Biological Chemistry; 278(44) pg43224-8
PubMed Id
First Author
Iqbal, J
Title
Leptin-mediated differential regulation of microsomal triglyceride transfer protein in the intestine and liver affects plasma lipids.
Citation
The Journal of Biological Chemistry; 295(13) pg4101-4113
PubMed Id
First Author
Maedler, K
Title
Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 101(21) pg8138-43
PubMed Id