Chemokines

Recombinant Human MDC (CCL22) (67 a.a.)

0 ReviewsSubmit a Review

Product Details

Catalogue Number: 300-36
Description:
Recombinant Human MDC (CCL22) (67 a.a.)

MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells, and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells, and exerts HIV-suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity, but retains HIV-suppressive activity. Recombinant Human MDC is an 8.0 kDa protein containing 67 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Source: E.coli

Synonyms: Macrophage-Derived Chemokine, CCL22, STCP-1, ABCD-1

AA Sequence: YGANMEDSVC CRDYVRYRLP LRVVKHFYWT SDSCPRPGVV LLTFRDKEIC ADPRVPWVKM ILNKLSQ

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human T cells using a concentration range of 10.0-100.0 ng/ml.

Calculated Molecular Weight: 8 kDa

Accession Number: O00626

Gene ID: 6367

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Anderson, C A
Title
A degradatory fate for CCR4 suggests a primary role in Th2 inflammation.
Citation
Journal of Leukocyte Biology; 107(3) pg455-466
PubMed Id
First Author
Pickering, R J
Title
Transactivation of RAGE mediates angiotensin-induced inflammation and atherogenesis.
Citation
The Journal of Clinical Investigation; 129(1) pg406-421
PubMed Id
First Author
Zhang, Y
Title
A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma.
Citation
Scientific Reports; 7(1) pg15038
PubMed Id