Recombinant Human/Murine/Rat Activin A (E.coli derived) 2 ReviewsSubmit a Review Product Details Catalogue Number: 120-14E Description: Activin A is a TGF-β family member that exhibits a wide range of biological activities, including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. Activin A binds to the two forms of activin receptor type I (Act RI-A and Act RI-B) and two forms of activin receptor type II (Act RII-A and Act RII-B). Activins are homodimers or heterodimers of different β subunits. They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand. Recombinant Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues. Source: E.coli Synonyms: Inhibin beta-1, FRP, FSH (Follicle-stimulating hormone)-releasing protein, Erythroid Differentiation Factor (EDF) AA Sequence (monomer): GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS Purity: ≥ 97% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by its ability to inhibit the proliferation of murine MPC-11 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg. Calculated Molecular Weight: 26 kDa Accession Number: P08476 Gene ID: 3624 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 1mg will be provided as 2x500μg. crossreactivity: Chicken, Dog, Frog, Human, Human + Mouse, Monkey, Mouse, Pig, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Organoids Angiogenesis/Cardiovascular Apoptosis Cancer Cell Culture Immune System Neurobiology Stem Cells & Differentiation TGF-β Superfamily Diabetes/Weight Regulation product.subtitle.recentcitations First Author Zhi, M Title Generation and characterization of stable pig pregastrulation epiblast stem cell lines. Citation Cell Research; PubMed Id 34848870 First Author Zhang, Y Title Synthetic liver fibrotic niche extracts achieve in vitro hepatoblasts phenotype enhancement and expansion. Citation Iscience; 24(11) pg103303 PubMed Id 34765922 First Author Gao, J Title Bone morphogenetic protein induces bone invasion of melanoma by epithelial-mesenchymal transition via the Smad1/5 signaling pathway Citation Laboratory investigation; a journal of technical methods and pathology; 101(11) pg1475-1483 PubMed Id 34504305 product.subtitle.productreviews Existing reviews Best product ever I use Activin A since 2008 for my differentiation protocols and I always got extraordinary results. If you want to use a reliable Recombinant Human growth factor, I highly recommend this. From: Giuseppe | Date: 22/07/2020 × Best product ever I use Activin A since 2008 for my differentiation protocols and I always got extraordinary results. If you want to use a reliable Recombinant Human growth factor, I highly recommend this. From: Giuseppe | Date: 22/07/2020 Close Consistent, great quality I have been using this product for my differentiations for the last 2 years and always gotten consistent and successful results. Highly recommend. From: Aylin | Date: 26/08/2020 × Consistent, great quality I have been using this product for my differentiations for the last 2 years and always gotten consistent and successful results. Highly recommend. From: Aylin | Date: 26/08/2020 Close
