Neurotrophins

Recombinant Human Neurturin

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Product Details

Catalogue Number: 450-11
Description:

Neurturin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, artemin, and persephin.  These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures.  Neurturin signals through a multicomponent receptor system, composed of RET and one of four GFRα (α1-α4) receptors.  Neurturin promotes the development and survival of sympathetic and sensory neurons by signaling through a receptor system composed of RET and GFRα2.  The functional form of human neurturin is a disulfide-linked homodimer, of two 11.8 kDa polypeptide monomers (204 total amino acid residues).  Each monomer contains seven conserved cysteine residues, one of which (Cys 69) is used for inter-chain disulfide bridging, and the others are involved in the intramolecular ring formation known as the cysteine-knot configuration.

Source: E.coli

Synonyms: NTN, NRTN

AA Sequence (monomer): ARLGARPCGL RELEVRVSEL GLGYASDETV LFRYCAGACE AAARVYDLGL RRLRQRRRLR RERVRAQPCC RPTAYEDEVS FLDAHSRYHT VHELSARECA CV

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Human Neurturin at a concentration of 100 ng/ml will support the survival of 65% of newborn rat sympathetic neurons.

Note:

1mg will be provided as 2x500μg.

Calculated Molecular Weight: 23.6 kDa

Accession Number: Q99748

Gene ID: 4902

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Peterson, S
Title
The RET and TRKA pathways collaborate to regulate neuroblastoma differentiation.
Citation
Oncogene; 23(1) pg213-25
PubMed Id
First Author
Schmutzler, B S
Title
Ret-dependent and Ret-independent mechanisms of Gfl-induced sensitization.
Citation
Molecular Pain; 7 pg22
PubMed Id
First Author
Pozas, E
Title
GDNF and GFRalpha1 promote differentiation and tangential migration of cortical GABAergic neurons.
Citation
Neuron; 45(5) pg701-13
PubMed Id