Neurotrophins

Recombinant Human β-NGF

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Product Details

Catalogue Number: 450-01
Description:
Recombinant Human β-NGF

β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4.  These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures.  β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems.  β-NGF also acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival.  The functional form of Recombinant Human β-NGF is a non-covalently-linked homodimer of two 13.5 kDa, polypeptide monomers that each contain 120 amino acids and three disulfide bonds, which are required for biological activity.

Source: E.coli

Synonyms: NGF-β, beta-Nerve Growth Factor

AA Sequence (monomer): SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by the dose-dependent stimulation of the proliferation of human TF-1 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.

This product has been tested against the WHO standard. International Unit information can be found here.

Recombinant Human beta-NGF Biological Activity

Calculated Molecular Weight: 27 kDa

Accession Number: P01138

Gene ID: 4803

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

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