Growth Factors & Cytokines

Recombinant Human Oncostatin M (209 a.a.)

Product Details

Catalogue Number: 300-10T
Description:

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis.  Produced by activated T cells, monocytes and Kaposi’s sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation.  It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi’s sarcoma cells, but inhibits the growth of some normal and tumor cell lines.  It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells.  OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF.  Human OSM is active on murine cells.  The human OSM gene encodes for a 252 amino acid polypeptide, containing 25 amino acid signal sequence for secretion and a 227 precursor protein.  Proteolytic processing of this precursor removes an 18 amino acid C-terminal peptide, and generates the mature OSM form.  Recombinant Human Oncostatin M is a 23.6 kDa protein, containing 209 amino acid residues.

Source: E.coli

Synonyms: OSM

AA Sequence: AAIGSCSKEY RVLLGQLQKQ TDLMQDTSRL LDPYIRIQGL DVPKLREHCR ERPGAFPSEE TLRGLGRRGF LQTLNATLGC VLHRLADLEQ RLPKAQDLER SGLNIEDLEK LQMARPNILG LRNNIYCMAQ LLDNSDTAEP TKAGRGASQP PTPTPASDAF QRKLEGCRFL HGYHRFMHSV GRVFSKWGES PNRSRRHSPH QALRKGVRR

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

Calculated Molecular Weight: 23.6 kDa

Accession Number: P13725

Gene ID: 5008

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Shee, K
Title
Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.
Citation
The Journal of Experimental Medicine; 215(3) pg895-910
PubMed Id
First Author
Edsbäcker, E
Title
STAT3 is activated in multicellular spheroids of colon carcinoma cells and mediates expression of IRF9 and interferon stimulated genes.
Citation
Stem Cell Reports; 9(1) pg536
PubMed Id
First Author
Bone, H K
Title
A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3.
Citation
Journal of Cell Science; 124(Pt 12) pg1992-2000
PubMed Id

product.subtitle.productreviews

Existing reviews
Excellent differentiation growth factor!
Like many of their other growth factors and cytokines, Peprotech oncostatin M helps my differentiation of human iPSCs run smoothly. I can count on their growth factors to arrive quickly and well-packaged. Once stored under clearly explained storage conditions, I don't worry about their stability. When differentiating human iPSCs, I get reproducible efficiencies of differentiation each time I use P... reviews.showmore
From:  Kendall | Date:  26/08/2020