Recombinant Human Oncostatin M (227 a.a.) 0 ReviewsSubmit a Review Product Details Catalogue Number: 300-10 Description: Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi’s sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi’s sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells. Recombinant Human Oncostatin M is a 25.7 kDa protein, containing 227 amino acid residues (full length precursor). Source: E.coli Synonyms: OSM AA Sequence: AAIGSCSKEY RVLLGQLQKQ TDLMQDTSRL LDPYIRIQGL DVPKLREHCR ERPGAFPSEE TLRGLGRRGF LQTLNATLGC VLHRLADLEQ RLPKAQDLER SGLNIEDLEK LQMARPNILG LRNNIYCMAQ LLDNSDTAEP TKAGRGASQP PTPTPASDAF QRKLEGCRFL HGYHRFMHSV GRVFSKWGES PNRSRRHSPH QALRKGVRRT RPSRKGKRLM TRGQLPR Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 2 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg. Calculated Molecular Weight: 25.7 kDa Accession Number: P13725 Gene ID: 5008 crossreactivity: Dog, Human, Human + Mouse, Monkey, Mouse, Pig, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Angiogenesis/Cardiovascular Bone, Skeletal, Cartilage Immune System Inflammation Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations First Author D'Alessio, J A Title Core promoter recognition complex changes accompany liver development. Citation Proceedings of the National Academy of Sciences of the United States of America; 108(10) pg3906-11 PubMed Id 21368148 First Author Radtke, S Title The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression. Citation The Journal of Biological Chemistry; 280(27) pg25760-8 PubMed Id 15894543 First Author Cameron, K Title Recombinant Laminins Drive the Differentiation and Self-Organization of hESC-Derived Hepatocytes. Citation Stem Cell Reports; 5(6) pg1250-1262 PubMed Id 26626180
