Growth Factors & Cytokines

Recombinant Human Prokineticin-2

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Product Details

Catalogue Number: 100-46
Description:
Recombinant Human Prokineticin-2

Prokineticin-2 (PK2) is a cysteine-rich secreted protein that is expressed in the testis and, in lower levels, in the small intestine. PK2 regulates various biological functions, including gastrointestinal motility, angiogenesis and circadian rhythms. It is closely related to EG-VEGF (Prokineticin-1), and binds to two orphan B-protein-coupled receptors termed PK-R1 and PK-R2. Recombinant Human Prokineticin-2 is an 8.8 kDa protein consisting of 81 amino acid residues, including ten cysteine residues that can potentially form five pairs of intra-molecular disulfide bonds.

Source: E.coli

Synonyms: PROK2, PK2, Protein Bv8 homolog

AA Sequence: AVITGACDKD SQCGGGMCCA VSIWVKSIRI CTPMGKLGDS CHPLTRKVPF FGRRMHHTCP CLPGLACLRT SFNRFICLAQ K

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Not available.

Calculated Molecular Weight: 8.8 kDa

Accession Number: Q9HC23

Gene ID: 60675

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Noda, K
Title
Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis
Citation
Scientific Reports; 11(1) pg18399
PubMed Id
First Author
Qureshi, R
Title
A Prokineticin-Driven Epigenetic Switch Regulates Human Epicardial Cell Stemness and Fate.
Citation
Stem cells (Dayton, Ohio); 36(10) pg1589-1602
PubMed Id
First Author
Xin, H
Title
G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells.
Citation
The Journal of Biological Chemistry; 288(19) pg13842-9
PubMed Id