Recombinant Human sTNF Receptor Type II 0 ReviewsSubmit a Review Product Details Catalogue Number: 310-12 Description: TNFRII is a member of the TNFR family of transmembrane proteins, and is expressed in immune cells and certain endothelial cells. It is a high affinity receptor for TNF-α, but manifests a lower affinity to TNF-β. Signaling through this receptor regulates various biological processes, including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. Soluble TNFRII is capable of inhibiting TNF-α-induced activities by acting as a decoy receptor. The human TNFRII gene encodes for a 461 amino acid type I transmembrane protein, which contains a 22 amino acid signal sequence, a 235 amino acid extracellular domain, a 30 amino acid transmembrane domain, and a 174 amino acid cytoplasmic domain. Recombinant Human sTNF Receptor Type II is an 18.9 kDa protein (174 amino acid residues) comprising the cysteine-rich, ligand binding portion of the extracellular domain of the TNFRII protein. Source: E.coli Synonyms: soluble Tumor Necrosis Factor Type II, TNFRSF1B, TNFR75, p75, CD120b, TNFR80, p80, TNFR2 AA Sequence: MAPEPGSTCR LREYYDQTAQ MCCSKCSPGQ HAKVFCTKTS DTVCDSCEDS TYTQLWNWVP ECLSCGSRCS SDQVETQACT REQNRICTCR PGWYCALSKQ EGCRLCAPLR KCRPGFGVAR PGTETSDVVC KPCAPGTFSN TTSSTDICRP HQICNVVAIP GNASMDAVCT STSP Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its inhibitory effect of the TNF-α mediated cytotoxicity in murine L-929 cells. The ED50 for this effect in the presence of 0.25 ng/ml of Recombinant Human TNF-α, is 0.125 µg/ml. Calculated Molecular Weight: 18.9 kDa Accession Number: P20333 Gene ID: 7133 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Apoptosis Immune System Inflammation Lipid Metabolism Neurobiology Receptors Stem Cells & Differentiation TNF Superfamily product.subtitle.recentcitations First Author Zheng, Z Title Screening of an anti-inflammatory peptide from Hydrophis cyanocinctus and analysis of its activities and mechanism in DSS-induced acute colitis. Citation Scientific Reports; 6 pg25672 PubMed Id 27158082 First Author Detrez, I Title Characterization and Application of a Unique Panel of Monoclonal Antibodies Generated against Etanercept. Citation Journal of immunology (Baltimore, Md. : 1950); 196(6) pg2879-84 PubMed Id 26843328 First Author Didangelos, A Title High-throughput proteomics reveal alarmins as amplifiers of tissue pathology and inflammation after spinal cord injury. Citation Scientific Reports; 6 pg21607 PubMed Id 26899371
