Recombinant Human TGF-β3 0 ReviewsSubmit a Review Product Details Catalogue Number: 100-36E Description: The three mammalian isoforms of TGF-β, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. The release of the biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. The physiological role of TGF-β3 is still unknown, but its expression pattern suggests a role in the regulation of certain development processes. Recombinant Human TGF-β3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond. Source: E.coli Synonyms: Transforming Growth Factor-β3 AA Sequence (monomer): ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by TGF-β3’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 25 kDa Accession Number: P10600 Gene ID: 7043 crossreactivity: Cow, Dog, Horse, Human, Human + Rat, Human + Virus, Monkey, Mouse, Pig, Rat, Sheep References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Cancer Immune System Inflammation Neurobiology Stem Cells & Differentiation TGF-β Superfamily Wound Healing Allergy product.subtitle.recentcitations First Author Ribeiro, T B Title Neuroprotection and immunomodulation by xenografted human mesenchymal stem cells following spinal cord ventral root avulsion. Citation Scientific Reports; 5 pg16167 PubMed Id 26548646 First Author Monzel, A S Title Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells. Citation Stem Cell Reports; 8(5) pg1144-1154 PubMed Id 28416282 First Author Bolognin, S Title 3D Cultures of Parkinson's Disease-Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing. Citation Advanced science (Weinheim, Baden-Wurttemberg, Germany); 6(1) pg1800927 PubMed Id 30643711