Growth Factors & Cytokines

Recombinant Human TL-1A

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Product Details

Catalogue Number: 310-23
Description:

TL-1A belongs to the TNF superfamily of ligands. It is expressed predominantly in endothelial cells, and to a lesser extent in the placenta, lung, kidney, skeletal muscle, pancreas, small intestine and colon. TL-1A inhibits endothelial cell proliferation and angiogenesis, and has been shown to induce NF-κB activation, caspase activity, and apoptosis in responding cell lines. TL-1A interacts with TNFRSF25/DR3 receptor, but can also bind to a decoy receptor TNFRSF21/DR6. Recombinant Human TL-1A is a 22.0 kDa polypeptide of 194 amino acid residues.

Source: E.coli

Synonyms: TNFSF15, VEGI

AA Sequence: QLRAQGEASV QFQALKGQEF APSHQQVYAP LRADGDKPRA HLTVVRQTPT QHFKNQFPAL HWEHELGLAF TKNRMNYTNK FLLIPESGDY FIYSQVTFRG MTSECSEIRQ AGRPNKPDSI TVVITKVTDS YPEPTQLLMG TKSVCEVGSN WFQPIYLGAM FSLQEGDKLM VNVSDISLVD YTKEDKTFFG AFLL

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate IFN-γ production by human PBMC using a concentration range of 10.0-100.0 ng/ml.
Note: Results may vary with PBMC donors.

Calculated Molecular Weight: 22 kDa

Accession Number: O95150

Gene ID: 9966

Note:

1mg will be provided as 2x500μg.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Li, J
Title
Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation.
Citation
Nature Communications; 10(1) pg3371
PubMed Id
First Author
Hedl, M
Title
A TNFSF15 disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8-induced IL-1.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 111(37) pg13451-6
PubMed Id
First Author
McLaren, J E
Title
The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro.
Citation
Journal of immunology (Baltimore, Md. : 1950); 184(10) pg5827-34
PubMed Id