Growth Factors & Cytokines

Recombinant Human TSLP

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Product Details

Catalogue Number: 300-62
Description:
Recombinant Human TSLP

TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7, and binds with the heterodimeric receptor complex consisting of the IL-7R α-chain (IL-7Rα) and the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibits apoptosis and stimulates growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes, and activates CD11c(+) dendritic cells (DCs). TSLP-activated DCs have been shown to prime naïve T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNF-α) while down-regulating IL-10 and IFN-γ, suggesting a role in initiating allergic inflammation. Recombinant Human TSLP is a 15.0 kDa protein consisting of 132 amino acid residues.

Source: E.coli

Synonyms: Thymic Stromal Lymphopoietin

AA Sequence: MYDFTNCDFE KIKAAYLSTI SKDLITYMSG TKSTEFNNTV SCSNRPHCLT EIQSLTFNPTAGCASLAKEM FAMKTKAALA IWCPGYSETQ INATQAMKKR RKRKVTTNKC LEQVSQLQGLWRRFNRPLLK QQ

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Not available.

Calculated Molecular Weight: 15 kDa

Accession Number: Q969D9

Gene ID: 85480

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Moreno Lorenzana, D
Title
CRLF2 and IKZF1 abnormalities in Mexican children with acute lymphoblastic leukemia and recurrent gene fusions: exploring surrogate markers of signaling pathways.
Citation
The Journal Of Pathology. Clinical Research; 7(4) pg410-421
PubMed Id
First Author
Arnold, I C
Title
The GM-CSF-IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses.
Citation
The Journal of Experimental Medicine; 217(12)
PubMed Id
First Author
Hedl, M
Title
STAT3 and STAT5 Signaling Thresholds Determine Distinct Regulation for Innate Receptor-Induced Inflammatory Cytokines, and
Citation
Journal of Immunology; 203(12) pg3325-3338
PubMed Id