Recombinant Human/Murine/Rat GDF-11 0 ReviewsSubmit a Review Product Details Catalogue Number: 120-11 Description: GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves the arrest of the progenitor cell cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their amino acid sequence, suggest that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. Recombinant Human/Murine/Rat GDF-11 is a 25.0 kDa disulfide-linked homodimer containing two 109 amino acid polypeptide chains. It is highly homologous to myostatin/GDF-8, sharing 90% amino acid sequence identity. Source: E.coli Synonyms: Growth/Differentiation Factor-11, BMP-11 AA Sequence (monomer): NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Assay #1: Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 0.08-0.10 µg/ml. Assay #2: Determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3/E1cells. The ED50 for this effect is 8-10 ng/ml. Calculated Molecular Weight: 25 kDa Accession Number: O95390 Gene ID: 10220 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 1mg will be provided as 2x500μg. crossreactivity: Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Cell Culture Immune System Stem Cells & Differentiation TGF-β Superfamily product.subtitle.recentcitations First Author Chu, K Title Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recognition. Citation The Journal of Biological Chemistry; 298(7) pg102076 PubMed Id 35643319 First Author Xu, Y Title GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation. Citation Oxidative Medicine And Cellular Longevity; 2021 pg8186877 PubMed Id 34712387 First Author Suh, J Title Similar sequences but dissimilar biological functions of GDF11 and myostatin Citation Experimental and Molecular Medicine; 52(10) pg1673-1693 PubMed Id 33077875
