Recombinant Murine BMP-4 0 ComentariosSubmit a Review Detalles del Producto Nùmero de Catalogo 315-27 Descripcion Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body, and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. PeproTech’s E.coli derived murine BMP-4 is a fully active homodimeric protein consisting of two 106 amino acid subunits which correspond to amino acids 303-408 of the full length BMP-4 precursor. The calculated molecular weight of Recombinant Murine BMP-4 is 23.9 kDa. Source: E.coli Synonyms: Bone Morphogenetic Protein-4, BMP-2B, DVR4 AA Sequence (monomer): KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-15 ng/ml. Calculated Molecular Weight: 23.9 kDa Accession Number: P21275 Gene ID: 12159 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 1mg will be provided as 2x500μg. crossreactivity: Mouse, References PubMed SDS Búsqueda del CoA Product Line Country Of Origin: USA Not for human use. Research Interest Organoids Angiogenesis/Cardiovascular Apoptosis Bone, Skeletal, Cartilage Cell Culture Immune System Neurobiology Stem Cells & Differentiation TGF-β Superfamily product.subtitle.recentcitations Primer autor Zhang, M Titulo The transcription factor TFCP2L1 promotes primordial germ cell-like cell specification of pluripotent stem cells. Citar The Journal of Biological Chemistry; pg101217 PudMed id 34555410 Primer autor Rore, H Titulo Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells Citar Communications Biology; 4(1) pg802 PudMed id 34183774 Primer autor Shin, S Titulo Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency. Citar Nature Communications; 12(1) pg3005 PudMed id 34021134