Recombinant Murine G-CSF 0 ReviewsSubmit a Review Product Details Catalogue Number: 250-05 Description: G-CSF is a hematopoietic growth factor that stimulates the development of committed progenitor cells to neutrophils and enhances the functional activities of the mature end-cell. It is produced in response to specific stimulation by a variety of cells, including macrophages, fibroblasts, endothelial cells and bone marrow stroma. G-CSF is being used clinically to facilitate hematopoietic recovery after bone marrow transplantation. Human and murine G-CSF are cross-species reactive. Recombinant Murine G-CSF is a 19.0 kDa protein consisting of 179 amino acid residues. Source: E.coli Synonyms: Granulocyte Colony-Stimulating Factor, CSF-3, MGI-1G, GM-CSFb, pluripoietin AA Sequence: MVPLVTVSAL PPSLPLPRSF LLKSLEQVRK IQASGSVLLE QLCATYKLCH PEELVLLGHS LGIPKASLSG CSSQALQQTQ CLSQLHSGLC LYQGLLQALS GISPALAPTL DLLQLDVANF ATTIWQQMEN LGVAPTVQPT QSAMPAFTSA FQRRAGGVLA ISYLQGFLET ARLALHHLA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine NFS-60 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg. Calculated Molecular Weight: 19 kDa Accession Number: P09920 Gene ID: 12985 crossreactivity: Human, Monkey, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Angiogenesis/Cardiovascular Cancer Diabetes/Weight Regulation Immune System Inflammation Stem Cells & Differentiation product.subtitle.recentcitations First Author de Bruin, A M Title IFNγ induces monopoiesis and inhibits neutrophil development during inflammation. Citation Blood; 119(6) pg1543-54 PubMed Id 22117048 First Author Gan, B Title mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Citation Proceedings of the National Academy of Sciences of the United States of America; 105(49) pg19384-9 PubMed Id 19052232 First Author van Oosten, A L Title JAK/STAT3 signalling is sufficient and dominant over antagonistic cues for the establishment of naive pluripotency. Citation Nature Communications; 3 pg817 PubMed Id 22569365
