Growth Factors & Cytokines

Recombinant Murine IFN-λ2

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Product Details

Catalogue Number: 250-33
Description:

IFN λ1, 2, and 3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and interferons.  All three IFN-lambdas use a distinct receptor system composed of an IFN- λR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14).  Signaling through this receptor system induces antiviral defenses similar to, but distinct from, that of type I interferons.  Recombinant Murine IFN- λ2 is a 19.8 kDa protein containing 175 amino acid residues.

Source: E.coli

Synonyms: IL-28A

AA Sequence: MDPVPRATRL PVEAKDCHIA QFKSLSPKEL QAFKKAKDAI EKRLLEKDMR CSSHLISRAW DLKQLQVQER PKALQAEVAL TLKVWENMTD SALATILGQP LHTLSHIHSQ LQTCTQLQAT AEPKPPSRRL SRWLHRLQEA QSKETPGCLE DSVTSNLFRL LTRDLKCVAS GDQCV

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to activate STAT following receptor-ligand interaction.

Calculated Molecular Weight: 19.8 kDa

Accession Number: Q4VK74

Gene ID: 330496

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Karki, R
Title
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes.
Citation
Cell; 184(1) pg149-168.e17
PubMed Id
First Author
Blumer, T
Title
SOCS1 is an inducible negative regulator of interferon λ (IFN-λ)-induced gene expression
Citation
The Journal of Biological Chemistry; 292(43) pg17928-17938
PubMed Id
First Author
Antony, F
Title
IFN-λ Regulates Neutrophil Biology to Suppress Inflammation in Herpes Simplex Virus-1-Induced Corneal Immunopathology.
Citation
Journal of immunology (Baltimore, Md. : 1950); 206(8) pg1866-1877
PubMed Id