Recombinant Murine IFN-λ2 0 ReviewsSubmit a Review Product Details Catalogue Number: 250-33 Description: IFN λ1, 2, and 3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and interferons. All three IFN-lambdas use a distinct receptor system composed of an IFN- λR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14). Signaling through this receptor system induces antiviral defenses similar to, but distinct from, that of type I interferons. Recombinant Murine IFN- λ2 is a 19.8 kDa protein containing 175 amino acid residues. Source: E.coli Synonyms: IL-28A AA Sequence: MDPVPRATRL PVEAKDCHIA QFKSLSPKEL QAFKKAKDAI EKRLLEKDMR CSSHLISRAW DLKQLQVQER PKALQAEVAL TLKVWENMTD SALATILGQP LHTLSHIHSQ LQTCTQLQAT AEPKPPSRRL SRWLHRLQEA QSKETPGCLE DSVTSNLFRL LTRDLKCVAS GDQCV Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to activate STAT following receptor-ligand interaction. Calculated Molecular Weight: 19.8 kDa Accession Number: Q4VK74 Gene ID: 330496 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, Virus References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Diabetes/Weight Regulation Immune System product.subtitle.recentcitations First Author McElrath, C Title Critical role of interferons in gastrointestinal injury repair Citation Nature Communications; 12(1) pg2624 PubMed Id 33976143 First Author Antony, F Title IFN-λ Regulates Neutrophil Biology to Suppress Inflammation in Herpes Simplex Virus-1-Induced Corneal Immunopathology. Citation Journal of immunology (Baltimore, Md. : 1950); 206(8) pg1866-1877 PubMed Id 33811102 First Author Jacob, J Title Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment. Citation Molecular therapy. Methods & clinical development; 20 pg324-336 PubMed Id 33511246
