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Growth Factors & Cytokines

Recombinant Murine IL-6

Detalles del Producto

Nùmero de Catalogo 216-16
Descripcion
Recombinant Murine IL-6

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant Murine IL-6 is a 21.7 kDa protein containing 188 amino acid residues.

Source: E.coli

Synonyms: 26 kDa protein, IFN-b2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2

AA Sequence: MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate the proliferation of mouse B9 cells.

This product has been tested against the WHO standard. International Unit information can be found here.

Recombinant Murine IL-6 Biological Activity Graph

Calculated Molecular Weight: 21.7 kDa

Accession Number: P08505

Gene ID: 16193

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

Primer autor
Dai, Y
Titulo
Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization.
Citar
Cell Reports; 40(12) pg111361
PudMed id
Primer autor
Zheng, X
Titulo
AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus.
Citar
The EMBO Journal; 41(6) pge108016
PudMed id
Primer autor
Ahmed, N
Titulo
Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation.
Citar
The Journal of Experimental Medicine; 219(1)
PudMed id

product.subtitle.productreviews

Comentarios existentes
Very Good
Used to treat cell as a proinflammatory stimulus.
De:  Yingjun | Fecha:  21/07/2020