Recombinant Murine IL-6 1 ReviewsSubmit a Review Product Details Catalogue Number: 216-16 Description: IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant Murine IL-6 is a 21.7 kDa protein containing 188 amino acid residues. Source: E.coli Synonyms: 26 kDa protein, IFN-b2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2 AA Sequence: MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of mouse B9 cells. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 21.7 kDa Accession Number: P08505 Gene ID: 16193 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Human + Hamster, Monkey, Mouse, Mouse + Bacteria, Mouse + Virus, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Cancer Cell Culture Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Allergy Transplantation product.subtitle.recentcitations First Author Dai, Y Title Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization. Citation Cell Reports; 40(12) pg111361 PubMed Id 36130501 First Author Zheng, X Title AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus. Citation The EMBO Journal; 41(6) pge108016 PubMed Id 35191555 First Author Ahmed, N Title Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation. Citation The Journal of Experimental Medicine; 219(1) PubMed Id 34817548 product.subtitle.productreviews Existing reviews Very Good Used to treat cell as a proinflammatory stimulus. From: Yingjun | Date: 21/07/2020 × Very Good Used to treat cell as a proinflammatory stimulus. From: Yingjun | Date: 21/07/2020 Close
