Recombinant Murine IL-9 0 ReviewsSubmit a Review Product Details Catalogue Number: 219-19 Description: IL-9 is an immunoregulatory cytokine produced by IL-2 activated Th2 lymphocytes. IL-9 enhances the proliferation of T lymphocytes, mast cells, erythroid precursor cells and megakaryoblastic leukemia cell lines. Over-expression of IL-9 has been implicated in the pathogenesis of anaplastic lymphoma and Hodgkin’s disease. Whereas murine IL-9 can function on human cells, human IL-9 is inactive on mouse cells. Recombinant Murine IL-9 is a 14.3 kDa protein of 127 amino acid residues, including 10 cysteine residues that are fully conserved between the human and murine proteins. Source: E.coli Synonyms: p40 cytokine, T-cell growth factor p40 AA Sequence: MQRCSTTWGI RDTNYLIENL KDDPPSKCSC SGNVTSCLCL SVPTDDCTTP CYREGLLQLT NATQKSRLLP VFHRVKRIVE VLKNITCPSF SCEKPCNQTM AGNTMSFLKS LLGTFQKTEM QRQKSRP Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent proliferation of human MO7e cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg. Calculated Molecular Weight: 14.3 kDa Accession Number: P15247 Gene ID: 16198 crossreactivity: Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Cancer Immune System product.subtitle.recentcitations First Author Regan-Komito, D Title GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis. Citation Nature Communications; 11(1) pg155 PubMed Id 31919358 First Author Ge, Q Title Homeostatic T cell proliferation in a T cell-dendritic cell coculture system. Citation Proceedings of the National Academy of Sciences of the United States of America; 99(5) pg2983-8 PubMed Id 11854473 First Author Zhao, Y Title Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells. Citation Nature Communications; 7 pg12368 PubMed Id 27492902
