Growth Factors & Cytokines

Recombinant Murine IL-9

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Product Details

Catalogue Number: 219-19
Description:

IL-9 is an immunoregulatory cytokine produced by IL-2 activated Th2 lymphocytes.  IL-9 enhances the proliferation of T lymphocytes, mast cells, erythroid precursor cells and megakaryoblastic leukemia cell lines.  Over-expression of IL-9 has been implicated in the pathogenesis of anaplastic lymphoma and Hodgkin’s disease.  Whereas murine IL-9 can function on human cells, human IL-9 is inactive on mouse cells.  Recombinant Murine IL-9 is a 14.3 kDa protein of 127 amino acid residues, including 10 cysteine residues that are fully conserved between the human and murine proteins.

Source: E.coli

Synonyms: p40 cytokine, T-cell growth factor p40

AA Sequence: MQRCSTTWGI RDTNYLIENL KDDPPSKCSC SGNVTSCLCL SVPTDDCTTP CYREGLLQLT NATQKSRLLP VFHRVKRIVE VLKNITCPSF SCEKPCNQTM AGNTMSFLKS LLGTFQKTEM QRQKSRP

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent proliferation of human MO7e cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.

Calculated Molecular Weight: 14.3 kDa

Accession Number: P15247

Gene ID: 16198

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

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Regan-Komito, D
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GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis.
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Nature Communications; 11(1) pg155
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Ge, Q
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Homeostatic T cell proliferation in a T cell-dendritic cell coculture system.
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Proceedings of the National Academy of Sciences of the United States of America; 99(5) pg2983-8
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Zhao, Y
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Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells.
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