Growth Factors & Cytokines

Recombinant Murine Leptin

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Product Details

Catalogue Number: 450-31
Description:
Recombinant Murine Leptin

Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Murine Leptin is a 16.2 kDa protein containing 147 amino acid residues.

Source: E.coli

Synonyms: Obesity protein (OB)

AA Sequence: MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSAKQRVTGL DFIPGLHPIL SLSKMDQTLA VYQQVLTSLP SQNVLQIAND LENLRDLLHL LAFSKSCSLP QTSGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDVSPEC

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: PeproTech's Murine Leptin has been shown to be biologically active in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls.

Calculated Molecular Weight: 16.2 kDa

Accession Number: P41160

Gene ID: 16846

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Porniece Kumar, M
Title
Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity.
Citation
Nature Metabolism; 3(12) pg1662-1679
PubMed Id
First Author
Heiss, C N
Title
The gut microbiota regulates hypothalamic inflammation and leptin sensitivity in Western diet-fed mice via a GLP-1R-dependent mechanism.
Citation
Cell Reports; 35(8) pg109163
PubMed Id
First Author
Takenaga, K
Title
Obesity reduces the anticancer effect of AdipoRon against orthotopic pancreatic cancer in diet-induced obese mice.
Citation
Scientific Reports; 11(1) pg2923
PubMed Id