Recombinant Murine MCP-2 (CCL8)

Product Details

Catalogue Number: 250-14

Description:

The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated Tcells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Murine MCP-2 is an 8.5 kDa protein containing 74 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Source: E.coli

Synonyms: Monocyte Chemotactic Protein-2, CCL8, HC14

AA Sequence: GPDKAPVTCC FHVLKLKIPL RVLKSYERIN NIQCPMEAVV FQTKQGMSLC VDPTQKWVSE YMEILDQKSQ ILQP

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10.0-100.0 ng/ml.

Calculated Molecular Weight: 8.5 kDa

Accession Number: Q9Z121

Gene ID: 20307

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

crossreactivity:

Human, Mouse, Pig

Country Of Origin: USA

Not for human use.

Research Interest

Angiogenesis/Cardiovascular

product.subtitle.recentcitations

First Author

Złotkowska, A

Title

Chemokines as the modulators of endometrial epithelial cells remodelling.

Citation

Scientific Reports; 9(1) pg12968

PubMed Id

31506569

First Author

Sokol, C L

Title

The Chemokine Receptor CCR8 Promotes the Migration of Dendritic Cells into the Lymph Node Parenchyma to Initiate the Allergic Immune Response.

Citation

Immunity; 49(3) pg449-463.e6

PubMed Id

30170811

First Author

Yagawa, Y

Title

Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy.

Citation

Scientific Reports; 7(1) pg15996

PubMed Id

29167448

Chemokines