Chemokines

Recombinant Murine MDC (CCL22)

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Product Details

Catalogue Number: 250-23
Description:

MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells, and exerts HIV-suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity, but retains HIV-suppressive activity. Recombinant Murine MDC is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Source: E.coli

Synonyms: Macrophage-Derived Chemokine, CCL22, STCP-1, ABCD-1

AA Sequence: GPYGANVEDS ICCQDYIRHP LPSRLVKEFF WTSKSCRKPG VVLITVKNRD ICADPRQVWV KKLLHKLS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract murine BW5147.3 cells using a concentration range of 1-30 ng/ml.

Calculated Molecular Weight: 7.8 kDa

Accession Number: O88430

Gene ID: 20299

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Singh, K
Title
Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.
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Scientific Reports; 7(1) pg4267
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Yagawa, Y
Title
Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy.
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Scientific Reports; 7(1) pg15996
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First Author
Kishore, M
Title
Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.
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Immunity; 47(5) pg875-889.e10
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