Recombinant Murine β-NGF 0 ReviewsSubmit a Review Product Details Catalogue Number: 450-34 Description: β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival. The functional form of Recombinant Murine β-NGF is a non-covalently-linked homodimer of two 13.4 kDa, polypeptide monomers that each contain 120 amino acids and three disulfide bonds, which are required for biological activity. Source: E.coli Synonyms: NGF-β, beta-Nerve Growth Factor AA Sequence (monomer): SSTHPVFHMG EFSVCDSVSV WVGDKTTATD IKGKEVTVLA EVNINNSVFR QYFFETKCRA SNPVESGCRG IDSKHWNSYC TTTHTFVKAL TTDEKQAAWR FIRIDTACVC VLSRKATRRG Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg. Calculated Molecular Weight: 26.8 kDa Accession Number: P01139 Gene ID: 18049 crossreactivity: Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Chemotaxis Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing product.subtitle.recentcitations First Author Renz, B W Title β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer. Citation Cancer Cell; 33(1) pg75-90.e7 PubMed Id 29249692 First Author Pereira, J A Title Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system. Citation The Journal of Cell Biology; 185(1) pg147-61 PubMed Id 19349584 First Author Ishihara, J Title Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing. Citation Nature Communications; 9(1) pg2163 PubMed Id 29867149
