Chemokines

Recombinant Murine RANTES (CCL5)

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Product Details

Catalogue Number: 250-07
Description:
Recombinant Murine RANTES (CCL5)

RANTES is a CC chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant Murine RANTES is a 7.8 kDa protein containing 68 amino acid residues, including the four highly conserved cysteine residues present in the CC chemokines.

Source: E.coli

Synonyms: Regulation upon Activation Normal T cell Express Sequence, CCL5, SIS-delta

AA Sequence: SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human activated T cells cultured in the presence of IL-2 using a concentration range of 10-30 ng/ml.

Calculated Molecular Weight: 7.8 kDa

Accession Number: P30882

Gene ID: 20304

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

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Du, Y
Title
Chemokines form nanoparticles with DNA and can superinduce TLR-driven immune inflammation.
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The Journal of Experimental Medicine; 219(7)
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Uzhachenko, R V
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Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors.
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Cell Reports; 35(1) pg108944
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Neddylation pathway alleviates chronic pancreatitis by reducing HIF1α-CCL5-dependent macrophage infiltration.
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