RELMβ (Resistin-like molecule β/FIZZ2) is a disulfide-linked, homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELMβ, and its molecular targets, are not fully known, but it has been suggested that it plays a regulatory role during inflammation, and may also act to establish links among adipose tissue, the intestine and the liver. Interestingly, the molecular structure of RELMβ is highly homologous to that of the adipose-derived cytokines, resistin and RELMα. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Murine RELMβ is an 18.0 kDa protein, consisting of two identical 83 amino acid polypeptide chains linked by a single disulfide bond.
Resistin-like β, Cysteine-rich secreted protein FIZZ2
AA Sequence (monomer):
MQCSFESLVD QRIKEALSRQ EPKTISCTSV TSSGRLASCP AGMVVTGCAC GYGCGSWDIR NGNTCHCQCS VMDWASARCC RMA
≥ 98% by SDS-PAGE gel and HPLC analyses.
Calculated Molecular Weight:
Country Of Origin: USA
Not for human use.
LeMessurier, K S
Chronic features of allergic asthma are enhanced in the absence of resistin-like molecule-beta.
Scientific Reports; 8(1) pg7061
Resistin-like molecule beta activates MAPKs, suppresses insulin signaling in hepatocytes, and induces diabetes, hyperlipidemia, and fatty liver in transgenic mice on a high fat diet.
The Journal of Biological Chemistry; 280(51) pg42016-25
Herbert, D R
Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection.
The Journal of Experimental Medicine; 206(13) pg2947-57