Recombinant Murine SDF-1α (CXCL12) 0 ReviewsSubmit a Review Product Details Catalogue Number: 250-20A Description: SDF-1α and β are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1α and β chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1α and β contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1α protein is the result of alternative splicing of the SDF-1 gene and contains 68 amino acid residues. Recombinant Murine SDF-1α is a 7.9 kDa protein containing 68 amino acid residues. Source: E.coli Synonyms: Stromal-Cell Derived Factor-1, CXCL12, PBSF AA Sequence: KPVSLSYRCP CRFFESHIAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human peripheral blood monocytes using a concentration of 50-100 ng/ml. Calculated Molecular Weight: 7.9 kDa Accession Number: P40224 Gene ID: 20315 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Leech, Mouse, Pig, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Chemotaxis Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing product.subtitle.recentcitations First Author Du, Y Title Chemokines form nanoparticles with DNA and can superinduce TLR-driven immune inflammation. Citation The Journal of Experimental Medicine; 219(7) PubMed Id 35640018 First Author Cao, L Title Inhibition of host Ogr1 enhances effector CD8+ T-cell function by modulating acidic microenvironment Citation Cancer Gene Therapy; 28(10-11) pg1213-1224 PubMed Id 34158625 First Author Lazarian, G Title A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation. Citation Cancer Cell; 39(3) pg380-393.e8 PubMed Id 33689703