Recombinant Murine SDF-1α (CXCL12) 0 ReviewsSubmit a Review Product Details Catalogue Number: 250-20A Description: SDF-1α and β are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1α and β chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1α and β contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1α protein is the result of alternative splicing of the SDF-1 gene and contains 68 amino acid residues. Recombinant Murine SDF-1α is a 7.9 kDa protein containing 68 amino acid residues. Source: E.coli Synonyms: Stromal-Cell Derived Factor-1, CXCL12, PBSF AA Sequence: KPVSLSYRCP CRFFESHIAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human peripheral blood monocytes using a concentration of 50-100 ng/ml. Calculated Molecular Weight: 7.9 kDa Accession Number: P40224 Gene ID: 20315 crossreactivity: Human, Leech, Mouse, Pig, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Chemotaxis Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing product.subtitle.recentcitations First Author Lazarian, G Title A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation. Citation Cancer Cell; 39(3) pg380-393.e8 PubMed Id 33689703 First Author Marlow, R Title Vascular Robo4 restricts proangiogenic VEGF signaling in breast. Citation Proceedings of the National Academy of Sciences of the United States of America; 107(23) pg10520-5 PubMed Id 20498081 First Author Huebsch, N Title Ultrasound-triggered disruption and self-healing of reversibly cross-linked hydrogels for drug delivery and enhanced chemotherapy. Citation Proceedings of the National Academy of Sciences of the United States of America; 111(27) pg9762-7 PubMed Id 24961369