Recombinant Murine SDF-1α (CXCL12)

Product Details

Catalogue Number: 250-20A

Description:

SDF-1α and β are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1α and β chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1α and β contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1α protein is the result of alternative splicing of the SDF-1 gene and contains 68 amino acid residues. Recombinant Murine SDF-1α is a 7.9 kDa protein containing 68 amino acid residues.

Source: E.coli

Synonyms: Stromal-Cell Derived Factor-1, CXCL12, PBSF

AA Sequence: KPVSLSYRCP CRFFESHIAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human peripheral blood monocytes using a concentration of 50-100 ng/ml.

Calculated Molecular Weight: 7.9 kDa

Accession Number: P40224

Gene ID: 20315

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

crossreactivity:

Human, Leech, Mouse, Pig, Rat

Country Of Origin: USA

Not for human use.

Research Interest

Stem Cells & Differentiation

Wound Healing

product.subtitle.recentcitations

First Author

Du, Y

Title

Chemokines form nanoparticles with DNA and can superinduce TLR-driven immune inflammation.

Citation

The Journal of Experimental Medicine; 219(7)

PubMed Id

35640018

First Author

Cao, L

Title

Inhibition of host Ogr1 enhances effector CD8+ T-cell function by modulating acidic microenvironment

Citation

Cancer Gene Therapy; 28(10-11) pg1213-1224

PubMed Id

34158625

First Author

Lazarian, G

Title

A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation.

Citation

Cancer Cell; 39(3) pg380-393.e8

PubMed Id

33689703

Chemokines