Chemokines

Recombinant Rat GRO-β/MIP-2 (CXCL2)

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Product Details

Catalogue Number: 400-11
Description:

All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant Rat GRO-β/MIP-2 is a 7.9 kDa protein consisting of 73 amino acids, including the 'ELR' motif common to the CXC chemokine family that binds to CXCR1 or CXCR2.

Source: E.coli

Synonyms: Growth Regulated Protein/Melanoma Growth Stimulatory Activity (MGSAβ), CXCL2, Macrophage Inflammatory Protein-2, MIP-2α, GRO2

AA Sequence: VVVASELRCQ CLTTLPRVDF KNIQSLTVTP PGPHCAQTEV IATLKDGHEV CLNPEAPLVQ RIVQKILNKG KAN

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract rat neutrophils using a concentration range of 10.0-100.0 ng/ml.

Calculated Molecular Weight: 7.9 kDa

Accession Number: P30348

Gene ID: 114105

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Nabah, Y N
Title
Angiotensin II induces neutrophil accumulation in vivo through generation and release of CXC chemokines.
Citation
Circulation; 110(23) pg3581-6
PubMed Id
First Author
Trettel, F
Title
Ligand-independent CXCR2 dimerization.
Citation
The Journal of Biological Chemistry; 278(42) pg40980-8
PubMed Id
First Author
Limatola, C
Title
The growth-related gene product beta induces sphingomyelin hydrolysis and activation of c-Jun N-terminal kinase in rat cerebellar granule neurones.
Citation
The Journal of Biological Chemistry; 274(51) pg36537-43
PubMed Id