Chemokines

Recombinant Rat SDF-1β (CXCL12)

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Product Details

Catalogue Number: 400-32B
Description:

SDF-1α and β are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1α and β chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1α and β contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1β protein, produced by an N-terminal truncation of two additional amino acids, after removal of the signal sequence, contains 72 amino acid residues. Recombinant Rat SDF-1β is an 8.4 kDa protein containing 72 amino acid residues.

Source: E.coli

Synonyms: Stromal-Cell Derived Factor-1, CXCL12, PBSF

AA Sequence: KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKSNNRQVC IDPKLKWIQE YLDKALNKRL KM

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human monocytes using a concentration range of 100.0-200.0 ng/ml.

Calculated Molecular Weight: 8.4 kDa

Accession Number: Q9QZD1

Gene ID: 24772

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Chen, D
Title
Crosstalk between SDF-1/CXCR4 and SDF-1/CXCR7 in cardiac stem cell migration.
Citation
Scientific Reports; 5 pg16813
PubMed Id
First Author
Bakondi, B
Title
Multimodal Delivery of Isogenic Mesenchymal Stem Cells Yields Synergistic Protection from Retinal Degeneration and Vision Loss
Citation
Stem Cells Translational Medicine; 6(2) pg444-457
PubMed Id