Chemokines

Recombinant Rat SDF-1α (CXCL12)

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Product Details

Catalogue Number: 400-32A
Description:
Recombinant Rat SDF-1α (CXCL12)

SDF-1α and β are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1α and β chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1α and β contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1α protein is the result of alternative splicing of the SDF-1 gene and contains 68 amino acid residues. Recombinant Rat SDF-1α is a 7.9 kDa protein containing 68 amino acid residues.

Source: E.coli

AA Sequence: KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKSNNRQVC IDPKLKWIQE YLDKALNK

Synonyms: Stromal-Cell Derived Factor-1, CXCL12, PBSF

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 50.0-100.0 ng/ml.

Calculated Molecular Weight: 7.9 kDa

Accession Number: Q9QZD1

Gene ID: 24772

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Pouzol, L
Title
ACT-1004-1239, a first-in-class CXCR7 antagonist with both immunomodulatory and promyelinating effects for the treatment of inflammatory demyelinating diseases.
Citation
FASEB journal : official publication of the Federation of American Societies for Experimental Biology; 35(3) pge21431
PubMed Id
First Author
Jayasuriya, C T
Title
Human Cartilage-Derived Progenitors Resist Terminal Differentiation and Require CXCR4 Activation to Successfully Bridge Meniscus Tissue Tears.
Citation
Stem cells (Dayton, Ohio); 37(1) pg102-114
PubMed Id
First Author
Renko, O
Title
SDF1 gradient associates with the distribution of c-Kit+ cardiac cells in the heart.
Citation
Scientific Reports; 8(1) pg1160
PubMed Id