Recombinant Rat SDF-1α (CXCL12)

Product Details

Catalogue Number: 400-32A

Description:

SDF-1α and β are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1α and β chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1α and β contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1α protein is the result of alternative splicing of the SDF-1 gene and contains 68 amino acid residues. Recombinant Rat SDF-1α is a 7.9 kDa protein containing 68 amino acid residues.

Source: E.coli

AA Sequence: KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKSNNRQVC IDPKLKWIQE YLDKALNK

Synonyms: Stromal-Cell Derived Factor-1, CXCL12, PBSF

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 50.0-100.0 ng/ml.

Calculated Molecular Weight: 7.9 kDa

Accession Number: Q9QZD1

Gene ID: 24772

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

crossreactivity:

Human, Human + Rat, Rat

Country Of Origin: USA

Not for human use.

Research Interest

Stem Cells & Differentiation

Wound Healing

product.subtitle.recentcitations

First Author

Pouzol, L

Title

ACT-1004-1239, a first-in-class CXCR7 antagonist with both immunomodulatory and promyelinating effects for the treatment of inflammatory demyelinating diseases.

Citation

FASEB journal : official publication of the Federation of American Societies for Experimental Biology; 35(3) pge21431

PubMed Id

33595155

First Author

Jayasuriya, C T

Title

Human Cartilage-Derived Progenitors Resist Terminal Differentiation and Require CXCR4 Activation to Successfully Bridge Meniscus Tissue Tears.

Citation

Stem cells (Dayton, Ohio); 37(1) pg102-114

PubMed Id

30358021

First Author

Renko, O

Title

SDF1 gradient associates with the distribution of c-Kit+ cardiac cells in the heart.

Citation

Scientific Reports; 8(1) pg1160

PubMed Id

29348441

Chemokines