Anticorps Monoclonaux

Biogems

Anti-Human CD80 (B7-1) Purified (Clone#: 2D10.4)

Détails du Produit

Catalog Number: 02911-20
Description:
The 2D10.4 antibody reacts with human CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.

Source: Isotype: Mouse IgG1, kappa; Clone#: 2D10.4

Note:

Product supplied by Biogems

Cross Reactivity:
Human
Research Interest

Country Of Origin: USA

Not for human use.