Recombinant Human ApoA-I 0 ReviewsSubmit a Review Product Details Catalogue Number: 350-11 Description: ApoA-I is a 29.0 kDa protein produced in the liver and intestine, and secreted as the predominant constituent of nascent high density lipoprotein (HDL) particle. ApoA-I, which is found exclusively in HDL, has a unique ability to capture and solubilize free cholesterol. This ApoA-I ability enables HDL to remove excess peripheral cholesterol, and return it to the liver for recycling and excretion. This process, called reverse cholesterol transport, is thought to inhibit atherogenesis. For this reason, HDL is also known as the "good cholesterol". The therapeutic potential of ApoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of ApoA-I (called ApoA-I Milano). The availability of recombinant normal ApoA-I should facilitate further investigation into the potential usefulness of ApoA-I in preventing atherosclerotic vascular diseases. Recombinant Human ApoA-I is a 28.2 kDa protein of 244 amino acid residues. Source: E.coli Synonyms: Apolipoprotein A-I AA Sequence: MDEPPQSPWD RVKDLATVYV DVLKDSGRDY VSQFEGSALG KQLNLKLLDN WDSVTSTFSK LREQLGPVTQ EFWDNLEKET EGLRQEMSKD LEEVKAKVQP YLDDFQKKWQ EEMELYRQKV EPLRAELQEG ARQKLHELQE KLSPLGEEMR DRARAHVDAL RTHLAPYSDE LRQRLAARLE ALKENGGARL AEYHAKATEH LSTLSEKAKP ALEDLRQGLL PVLESFKVSF LSALEEYTKK LNTQ Purity: ≥ 97% by SDS-PAGE gel and HPLC analyses. Biological Activity: Not available. Calculated Molecular Weight: 28.2 kDa Accession Number: P02647 Gene ID: 335 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Hamster, Human, References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Immune System Inflammation product.subtitle.recentcitations First Author Burgess, E J Title Bacterial Lipoproteins Constitute the TLR2-Stimulating Activity of Serum Amyloid A. Citation Journal of immunology (Baltimore, Md. : 1950); 201(8) pg2377-2384 PubMed Id 30158125 First Author Cai, H Title Serum amyloid A induces monocyte tissue factor. Citation Journal of immunology (Baltimore, Md. : 1950); 178(3) pg1852-60 PubMed Id 17237436 First Author van der Westhuyzen, D R Title Serum amyloid A promotes cholesterol efflux mediated by scavenger receptor B-I. Citation The Journal of Biological Chemistry; 280(43) pg35890-5 PubMed Id 16120612