Autres Protéines

Recombinant Human BD-3

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Product Details

Catalogue Number: 300-52
Description:
Recombinant Human BD-3

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system.  The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds.  To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6.  β-defensins are expressed on some leukocytes and at epithelial surfaces.  In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells.  The β-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence.  β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds.  Recombinant Human BD-3 is a 5.1 kDa protein containing 45 amino acid residues.

Source: E.coli

Synonyms: Beta-Defensin 3, DEFB3, DEFB103A

AA Sequence: GIINTLQKYY CRVRGGRCAV LSCLPKEEQI GKCSTRGRKC CRRKK

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Exhibits antimicrobial activity against gram-positive bacteria S. aureus and gram-negative P. aeruginosa and E.coli.

Calculated Molecular Weight: 5.1 kDa

Accession Number: P81534

Gene ID: 55894

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Ting, D S
Title
Hybrid derivative of cathelicidin and human beta defensin-2 against Gram-positive bacteria: A novel approach for the treatment of bacterial keratitis
Citation
Scientific Reports; 11(1) pg18304
PubMed Id
First Author
Abou Alaiwa, M H
Title
pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 111(52) pg18703-8
PubMed Id
First Author
Dietrich, D E
Title
Human β-defensin HBD3 binds to immobilized Bla g2 from the German cockroach (Blattella germanica).
Citation
Peptides; 53 pg265-9
PubMed Id