Recombinant Human Cardiotrophin-1 0 ReviewsSubmit a Review Product Details Catalogue Number: 300-32 Description: CT-1 is a member of the IL-6 family of cytokines which also includes LIF, CNTF, OSM (Oncostatin M), IL-11, IL-6 and possibly NNT-1/BCSF-3. CT-1 is a pleiotropic cytokine which is expressed in various tissues including the adult heart, skeletal muscle, ovary, colon, prostate and fetal lung, and signals through the LIF receptor and the gp130 receptor subunit. CT-1 has the ability to induce cardiac myocyte hypertrophy, and enhances the survival of cardiomyocyte and different neuronal populations. Biologically active human CT-1 is synthesized as a 201 amino acid polypeptide lacking a hydrophobic N-terminal secretion signal sequence. Recombinant Human CT-1 is a 21.1 kDa protein consisting of 200 amino acid residues. Source: E.coli Synonyms: CT-1 AA Sequence: SRREGSLEDP QTDSSVSLLP HLEAKIRQTH SLAHLLTKYA EQLLQEYVQL QGDPFGLPSF SPPRLPVAGL SAPAPSHAGL PVHERLRLDA AALAALPPLL DAVCRRQAEL NPRAPRLLRR LEDAARQARA LGAAVEALLA ALGAANRGPR AEPPAATASA ASATGVFPAK VLGLRVCGLY REWLSRTEGD LGQLLPGGSA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent proliferation of TF-1 cells was ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg. Calculated Molecular Weight: 21.1 kDa Accession Number: Q16619 Gene ID: 1489 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Bone, Skeletal, Cartilage Immune System Neurobiology product.subtitle.recentcitations First Author Salvi, M Title Automated Segmentation of Fluorescence Microscopy Images for 3D Cell Detection in human-derived Cardiospheres. Citation Scientific Reports; 9(1) pg6644 PubMed Id 31040327 First Author Iannolo, G Title MiR34 inhibition induces human heart progenitor proliferation. Citation Cell death & disease; 9(3) pg368 PubMed Id 29511160 First Author Wang, S Title JAK2-binding long noncoding RNA promotes breast cancer brain metastasis. Citation The Journal of Clinical Investigation; 127(12) pg4498-4515 PubMed Id 29130936
