Facteurs de Croissance et Cytokines

Recombinant Human Epigen

Product Details

Catalogue Number: 100-51
Description:

Epigen is an EGF-related polypeptide growth factor that signals through the ErbB receptor-1. It is produced in several tissues, including the testis, liver, and heart, as well as in certain tumor cells. Epigen is mitogenic for fibroblasts and epithelial cells. Human Epigen is initially synthesized as a glycosylated 14.7 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a mature soluble sequence. Recombinant Human Epigen is a 7.9 kDa monomeric protein, containing 72 amino acid residues, which comprises the EGF-homologous portion of the Epigen precursor.

Source: E.coli

Synonyms: EPG, Epithelial mitogen

AA Sequence: AVTVTPPITA QQADNIEGPI ALKFSHLCLE DHNSYCINGA CAFHHELEKA ICRCFTGYTG ERCEHLTLTS YA

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells. The expected ED50 for this effect is 150-300 ng/ml.

Calculated Molecular Weight: 7.9 kDa

Accession Number: Q6UW88

Gene ID: 255324

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Lindzen, M
Title
Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53
Citation
Oncogene; 40(21) pg3665-3679
PubMed Id
First Author
Ho, J
Title
Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor.
Citation
Nature Communications; 10(1) pg2297
PubMed Id