Facteurs de Croissance et Cytokines

Recombinant Human FGF-18

0 ReviewsSubmit a Review

Product Details

Catalogue Number: 100-28
Description:

FGF-18 is a heparin-binding growth factor that belongs to the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-18 is an essential regulator of long bone and calvarial development. FGF-18 signals through FGFR 1c, 2c, 3c, and 4. Recombinant Human FGF-18 derived from E.coli is a 20.1 kDa protein consisting of 173 amino acid residues, resulting from C-terminal truncation of the full length protein.

Source: E.coli

Synonyms: Fibroblast Growth Factor-18, zFGF5, FGFI

AA Sequence: AEENVDFRIH VENQTRARDD VSRKQLRLYQ LYSRTSGKHI QVLGRRISAR GEDGDKYAQL LVETDTFGSQ VRIKGKETEF YLCMNRKGKL VGKPDGTSKE CVFIEKVLEN NYTALMSAKY SGWYVGFTKK GRPRKGPKTR ENQQDVHFMK RYPKGQPELQ KPFKYTTVTK RSR

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 10 ng/ml, corresponding to a specific activity of ≥ 1 x 105 units/mg.

Calculated Molecular Weight: 20.1 kDa

Accession Number: O76093

Gene ID: 8817

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Merrill, A E
Title
Bent bone dysplasia-FGFR2 type, a distinct skeletal disorder, has deficient canonical FGF signaling.
Citation
American Journal of Human Genetics; 90(3) pg550-7
PubMed Id
First Author
Zhang, X
Title
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
Citation
The Journal of Biological Chemistry; 281(23) pg15694-700
PubMed Id
First Author
Smith, L B
Title
Fibroblast growth factor receptor 3 effects on proliferation and telomerase activity in sheep growth plate chondrocytes.
Citation
Journal of Animal Science and Biotechnology; 3(1) pg39
PubMed Id