Chémokines

Recombinant Human Fractalkine (CX3CL1)

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Product Details

Catalogue Number: 300-31
Description:
Recombinant Human Fractalkine (CX3CL1)

Fractalkine is a CX3CL chemokine that signals through the CX3CR1 receptor. Fractalkine has been shown to chemoattract monocytes, microglia cells and NK cells. Fractalkine is, at this time, the only CXC3C chemokine that contains three amino acid residues between the first and second cysteine residues of the chemokine domain. The Fractalkine gene encodes for a 397 amino acid precursor protein containing a 24 amino acid signal sequence, a chemokine domain, and a "mucin-like stalk" sequence, which is followed by the transmembrane domain containing approximately 20 amino acids, and a C-terminal cytoplasmic domain.  The extracellular chemokine domain contains 76 amino acid residues, including the four conserved cysteine residues found in other chemokines. Recombinant Human Fractalkine is an 8.5 kDa protein containing 76 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

Source: E.coli

Synonyms: Neurotactin, CX3CL1, FKN

AA Sequence: QHHGVTKCNI TCSKMTSKIP VALLIHYQQN QASCGKRAII LETRQHRLFC ADPKEQWVKD AMQHLDRQAA ALTRNG

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human T cells using a concentration range of 5.0-10.0 ng/ml.

Calculated Molecular Weight: 8.5 kDa

Accession Number: P78423

Gene ID: 6376

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Magusali, N
Title
A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene.
Citation
Brain : A Journal Of Neurology; 144(12) pg3727-3741
PubMed Id
First Author
De Groof, T W
Title
Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies
Citation
Nature Communications; 12(1) pg4357
PubMed Id
First Author
Liu, T
Title
Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE.
Citation
The Journal of Experimental Medicine; 217(12)
PubMed Id