Recombinant Human GDF-2 0 ReviewsSubmit a Review Product Details Catalogue Number: 120-07 Description: GDF-2 belongs to the TGF-β cytokine family, whose members play an important role during prenatal development and postnatal growth, and the remodeling and maintenance of a variety of tissues and organs. GDF-2 is expressed mainly in non-parenchymal cells of the liver, but is also found in other various cells and tissues. GDF-2 can signal through the ALK1 receptor, and has been implicated in a number of physiologic events including the regulation of the hepatic reticuloendothelial system, glucose homeostasis, iron homeostasis, and the inhibition of angiogenesis. Recombinant Human GDF-2 is a 24.1 kDa disulfide-linked homodimeric protein consisting of two 110 amino acid polypeptide chains. Source: CHO cells Synonyms: Growth/Differentiation Factor-2, BMP-9 AA Sequence (monomer): SAGAGSHCQK TSLRVNFEDI GWDSWIIAPKE YEAYECKGGC FFPLADDVTPTK HAIVQTLVHL KFPTKVGKAC CVPTKLSPIS VLYKDDMGVP TLKYHYEGMS VAECGCR Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.9 ng/ml. Calculated Molecular Weight: 24.1 kDa Accession Number: Q9UK05 Gene ID: 2658 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Cell Culture Immune System Neurobiology Stem Cells & Differentiation TGF-β Superfamily product.subtitle.recentcitations First Author Abdullah, A Title Netrin-1 functions as a suppressor of bone morphogenetic protein (BMP) signaling Citation Scientific Reports; 11(1) pg8585 PubMed Id 33883596 First Author Pous, L Title Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling. Citation Nature Communications; 11(1) pg630 PubMed Id 32005867 First Author Dufton, N P Title Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis. Citation Nature Communications; 8(1) pg895 PubMed Id 29026072
